Low rate of mother-to-child transmission of HIV-1 after nevirapine intervention in a pilot public health program in Yaounde, Cameroon
A Ayouba, G Tene, P Cunin… - JAIDS Journal of …, 2003 - journals.lww.com
A Ayouba, G Tene, P Cunin, Y Foupouapouognigni, E Menu, A Kfutwah, J Thonnon…
JAIDS Journal of Acquired Immune Deficiency Syndromes, 2003•journals.lww.comObjective: To determine the percentage of infected children for whom nevirapine (NVP) was
used to prevent peripartum mother-tochild transmission (MTCT) of HIV in Yaoundé,
Cameroon. Design: The study was a prospective Public Health Pilot Program covering a 3-
year period (January 2000-December 2002). Methods: Counseled and consenting HIV-1-
positive pregnant women were given a single dose of NVP at the onset of labor. Babies
were given 2 mg/kg NVP syrup within the first 72 hours of life. NVPtreated children were …
used to prevent peripartum mother-tochild transmission (MTCT) of HIV in Yaoundé,
Cameroon. Design: The study was a prospective Public Health Pilot Program covering a 3-
year period (January 2000-December 2002). Methods: Counseled and consenting HIV-1-
positive pregnant women were given a single dose of NVP at the onset of labor. Babies
were given 2 mg/kg NVP syrup within the first 72 hours of life. NVPtreated children were …
Abstract
Objective:
To determine the percentage of infected children for whom nevirapine (NVP) was used to prevent peripartum mother-tochild transmission (MTCT) of HIV in Yaoundé, Cameroon.
Design:
The study was a prospective Public Health Pilot Program covering a 3-year period (January 2000-December 2002).
Methods:
Counseled and consenting HIV-1-positive pregnant women were given a single dose of NVP at the onset of labor. Babies were given 2 mg/kg NVP syrup within the first 72 hours of life. NVPtreated children were regularly followed up and examined for HIV-1 infection at 6-8 weeks and 5-6 months through plasma viral load (VL) quantification with the bDNA system.
Results:
One hundred twenty-three children were diagnosed with perinatal HIV-1 infection at 6-8 weeks and 5-6 months. Thirteen children (10.6%[13/123]; 95% confidence interval, 5.1-16) were infected and presented with high VLs, in general> 500,000 copies/mL. Two children had intermediate VLs (between 50 and 3500 copies/mL) at both time points. One hundred seven children (87%) were considered not infected at 6-8 weeks of age.
Conclusions:
Our results indicate that the HIV-1 MTCT rate 6-8 weeks after NVP administration was not> 13%(16/123), thus demonstrating the effectiveness of NVP for lowering the risk of HIV-1 MTCT in real-life settings.
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